Ratatouille would be my number 2, although it seems hard to favour one above the other. They're both examples of what a good Pixar-movie should be: original, exploring new ways of storytelling, creating convincing characters without falling into clichés, or flat commercializing.
Just realizing when I was checking the wiki-article en.wikipedia.org/…. Has anyone of you seen "Up" yet? I haven't, since the theater-tickets are becoming too expensive for this student :) Another movie I'm leaning towards is "Despicable me".